CBS News Logo Experimental Ebola drug: Questions and answers about ZMapp

WASHINGTON -- An experimental Ebola drug has been used to treat two American aid workers and a Spanish missionary priest. Could Liberian doctors be next? The Liberian government said Monday that it will receive doses of the drug to treat two doctors in the country. They would be the first Africans to receive it. The manufacturer, Mapp Biopharmaceutical Inc., said in a statement posted Monday afternoon on its website that the supply of the drug is now exhausted. The announcement came as the World Health Organization considered ethical questions about who should get access to an experimental drug in an emergency. Some questions and answers about the Ebola drug: Q: What is this drug? A: Called ZMapp, it is a cocktail of specially engineered antibodies designed to target and inactivate the Ebola virus. Q: What do we know about whether it works? A: Very little. Various antibodies have been tested in small numbers of monkeys, but not people. In one study, 43 percent of treated monkeys survived when the drug was given after the animals showed symptoms. Mapp Biopharmaceutical now is developing a combination of three antibodies that seemed most promising in those animal studies. Q: Why isn't ZMapp being tested more widely to find out if it works in people? A: There's not enough available. The antibodies are grown inside tobacco plants, and then extracted and purified, a slow process. U.S. officials have estimated that only a modest amount could be produced in two or three months, unless some way to speed production is found. Q: What does it mean that the two American aid workers who received the drug are reported to be slowly improving? A: Top U.S. health officials stress that there's no way to know if the drug really helped, or if those two patients would have been among the 40 percent of people who are surviving this outbreak anyway. Without human studies, there also isn't any way to know if the drug might harm instead of help. There is no proven treatment for Ebola. But Continue Reading

Questions And Answers About Opioids And Chronic Pain

Your Health Facebook Twitter Flipboard Email Enlarge this image When it comes to chronic pain, how do patients and doctors find the right treatment? Hero Images/Getty Images hide caption toggle caption Hero Images/Getty Images When it comes to chronic pain, how do patients and doctors find the right treatment? Hero Images/Getty Images Millions of Americans use opioids to relieve pain. But many also struggle with addiction. This week, a report in JAMA, the journal of the American Medical Association, found that nonopioid painkillers — like acetaminophen and ibuprofen — were as effective as opioids at treating chronic back, hip and knee pain, and with fewer side effects. The findings raise a lot of questions about the right approach to managing pain, particularly chronic pain. So earlier this week, we asked listeners on Facebook and Twitter to share their questions about treating chronic pain. For answers, NPR's Ari Shapiro turned to Dr. Ajay Wasan, professor and vice chair for pain medicine at the University of Pittsburgh Medical Center. Questions and answers have been edited for length and clarity. Isn't it true that ... acetaminophen can be very damaging to the liver, particularly with daily long-term use? — Emma Juneau For treatment of chronic pain, especially arthritis pain, higher doses of acetaminophen have been recommended, and there are good studies supporting that it can be quite effective for pain. You get a cumulative effect with the higher doses. Those can also be associated with a rise in liver enzymes for some people. It would be very rare for those enzymes to reach a toxic level that would cause liver damage, but we don't know what percent of people get that little rise in liver enzymes, or the chances that a slight increase in liver enzymes will lead to liver damage. It raises a very excellent point, that nonopiate medications have some side effects as well. We know anti-inflammatories Continue Reading

Question and Answer with District judge candidates

The candidates are from 238th and 441st races Midland Reporter-Telegram Published 1:29 pm, Sunday, February 18, 2018 Photo: Photo: Aleksandar Radovanov - Fotolia Image 1of/1 CaptionClose Image 1 of 1 Buy photo Symbol of law and justice in the empty courtroom, law and justice concept FOTOLIA Symbol of law and justice in the empty courtroom, law and justice concept FOTOLIA Photo: Photo: Aleksandar Radovanov - Fotolia Buy this photo Question and Answer with District judge candidates 1 / 1 Back to Gallery Questionnaire  Full name. Age. Please describe your family, including number of times you have been married. State educational degrees which you have obtained and from where? State when you licensed as an attorney? Years lived in Midland County after becoming a licensed attorney? What areas of law is the concentration your law practice typically? Have you ever been subjected to discipline by the State Bar of Texas?  If so, what was the discipline and why? Have you ever been accused of, indicted for or convicted of a felony or a crime of moral turpitude?  If so, what was the offense and how was it disposed of? Have you ever had a lien filed against you and why?  If so, has it been fully paid? State how many criminal jury trials and how man civil jury trials you have tried to a verdict. What do regard to be your duties as a district judge? What do think the temperament of a judge should be?  What in your personality, if anything, do think you would have to aware of? What is the most important aspect of handling a docket of criminal and civil cases for a judge? What is your philosophy regarding interpretation of the law? Is there ever a situation when a judge should create new law Continue Reading

Questions and answers about security clearances

Questions and answers about security clearances Deb Riechmann, Associated Press February 13, 2018 Updated: February 13, 2018 6:49pm Photo: Evan Vucci, AP White House senior adviser Jared Kushner listens during a meeting between President Donald Trump and lawmakers about trade policy in the Cabinet Room of the White House, Tuesday, Feb. 13, 2018, in Washington. White House senior adviser Jared Kushner listens during a meeting... WASHINGTON (AP) — Rob Porter, who resigned as President Donald Trump's staff secretary following allegations of spousal abuse, was one of as many as two dozen senior White House officials, including the president's son-in-law, Jared Kushner, who hold interim security clearances. Express Newsletters Get the latest news, sports and food features sent directly to your inbox. Sign up Most Popular 1 Texas rancher sues feds, state after finding surveillance... 2 Spurs’ plans still revolve around belief in present 3 Air Force physicians’ child was season’s first Bexar flu... 4 With or without Holts, Spurs entrenched in stability 5 Alamo Heights home renovated for a modern family Kushner is still working without a permanent security clearance, according to an administration official familiar the process but not authorized to discuss it publicly. Interim clearances are routinely issued — some because of a massive government backlog of hundreds of thousands of security clearance reviews. A senior administration official said as many as two dozen senior officials don't hold permanent clearances. The official wasn't authorized to discuss the matter and spoke on the condition of anonymity. Questions and answers about security clearances: Q: How are government workers screened? A: The government conducts background investigations to make sure that job applicants or employees are suitable for employment. The scope of the Continue Reading

Questions and answers about executive privilege

Mark Sherman, Associated Press Updated 10:25 pm, Wednesday, January 17, 2018 Photo: Evan Vucci, AP Image 1of/1 CaptionClose Image 1 of 1 President Donald Trump speaks during a Congressional Gold Medal ceremony honoring former Sen, Bob Dole on Capitol Hill, Wednesday, Jan. 17, 2018, in Washington. President Donald Trump speaks during a Congressional Gold Medal ceremony honoring former Sen, Bob Dole on Capitol Hill, Wednesday, Jan. 17, 2018, in Washington. Photo: Evan Vucci, AP Questions and answers about executive privilege 1 / 1 Back to Gallery WASHINGTON (AP) — Presidents since George Washington have resisted congressional requests for documents and the testimony of administration officials by asserting a power known as executive privilege. Executive privilege is the president's power to keep information from the courts, Congress and the public to protect the confidentiality of presidential decision-making. Steve Bannon's refusal to answer questions from a congressional committee about his time working for President Donald Trump is raising new concerns that the White House is trying to control what current and former aides tell Congress. LATEST SFGATE VIDEOS Now Playing: Now Playing Tour of 1997 Volvo 'tiny home' Courtesy Lance Peterson The worst floods in northern California history Martin do Nascimento Marquette King vs Globetrotter in HORSE San Francisco Chronicle 1701 Franklin Street in San Francisco MAYER • VIDEO/ Vimeo Speedboat slams into fishing boat Salmon Trout Steelheader / Facebook Big waves at Mavericks: Jan. 15, 2018 Surfline Bus dash cam video shows near-miss with car San Francisco Chronicle Biking across frozen Caples Lake near Kirkwood, Calif. First Tracks Productions Helicopter and crew installing a new chairlift at Bear Valley Continue Reading

Questions and answers on dogs and Ebola risks

Monkeys, bats and a menagerie of animals can spread Ebola. Now there's worry that dogs — or one dog in particular — might spread it, too. Officials in Madrid got a court order to euthanize the pet of a Spanish nursing assistant who has the deadly virus. No case of Ebola spreading to people from dogs has ever been documented, but "clearly we want to look at all possibilities," said Dr. Thomas Frieden, director of the U.S. Centers for Disease Control and Prevention. Questions and answers about the situation: Q: Can dogs get Ebola? A: At least one major study suggests they can, without showing symptoms. Researchers tested dogs during the 2001-02 Ebola outbreak in Gabon after seeing some of them eating infected dead animals. Of the 337 dogs from various towns and villages, 9 to 25 percent showed antibodies to Ebola, a sign they were infected or exposed to the virus. Q: What's the risk to people? A: No one really knows. Lab experiments on other animals suggest their urine, saliva or stool might contain the virus. That means that in theory, people might catch it through an infected dog licking or biting them, or from grooming. Q: Why is this dog suspect? A: The nursing assistant and her husband have been in isolation since she tested positive for Ebola this week. She helped care for a missionary priest who died of Ebola. The Madrid regional government got a court order to euthanize their dog, saying "available scientific information" can't rule out "a risk of contagion." Q: Does everyone agree that's best? A: No. The dog's owners don't want it killed, and an animal rights group wants it quarantined instead, although it's not clear how effective that would be since infected dogs don't show symptoms, and it's not known how long the virus can last in them. Others protested outside Romero's house and took to Twitter proclaiming "#SalvemosAExcalibur" ("Let's save Excalibur"). Continue Reading

Gowdy on Hillary’s Remarks: ‘Left With More Questions Than Answers’

Hillary Clinton this afternoon defended her use of a personal email account during her time at the State Department. At the time, she said she opted “for convenience” in using one email account, which was allowed by the State Department. Looking back, she said it probably would have been better to use a second email account, “but at the time, this didn’t seem like an issue.” Rep. Trey Gowdy (R-S.C.), chairman of the House Select Committee on Benghazi, responded with a written statement, saying "serious questions" remain about this issue.  Read his response below and tune in tonight at 7p ET as Gowdy goes "On the Record" with Greta Van Susteren.  “Having finally heard from Secretary Clinton about her exclusive use of personal email with which to conduct official business while serving as Secretary of State, regrettably we are left with more questions than answers. For instance, there remain serious questions about the security of the system she employed from a national security standpoint, who authorized this exclusive use of personal email despite guidance to the contrary from both her State Department and the White House, who had access to the server from the time Secretary Clinton left office until the time—almost two years later—the State Department asked for these public records back, and who culled through the records to determine which were personal and which were public. “Without access to Secretary Clinton’s personal server, there is no way for the State Department to know it has acquired all documents that should be made public, and given State’s delay in disclosing the fact Secretary Clinton exclusively used personal email to conduct State business, there is no way to accept State’s or Secretary Clinton’s certification she has turned over all documents that rightfully belong to the American people. That is why I see no choice but for Secretary Clinton to turn her Continue Reading

66 questions and answers about the government shutdown

WASHINGTON — It's been 17 years since the federal government last faced a partial shutdown because Congress and the president couldn't agree on a spending bill. A lot has changed in that time, leaving federal employees, citizens and even government decision-makers confused about what a shutdown would mean.Every shutdown is different. The politics that cause them are different. Because of technology and structural overhauls, the way the government functions has changed since 1996. Much of what will happen is unknown. UPDATE: 27 more questions and answers about the shutdown TWITTER: Ask your questions via TwitterHere's what we do know about Tuesday's looming shutdown: THE BASICS 1. What causes a shutdown? Under the Constitution, Congress must pass laws to spend money. If Congress can't agree on a spending bill — or if, in the case of the Clinton-era shutdowns, the president vetoes it — the government does not have the legal authority to spend money.2. What's a continuing resolution? Congress used to spend money by passing a budget first, then 12 separate appropriations bills. That process has broken down, and Congress uses a stopgap continuing resolution, or CR, that maintains spending at current levels for all or part of the year.3. Why can't Congress agree? The Republican-controlled House has passed a spending bill that maintains spending levels but does not provide funding to implement the Affordable Care Act, or Obamacare. The Democratic Senate insists that the program be fully funded and that Congress pass what they call a "clean" CR.4. What is a "clean" CR?A continuing resolution without policy changes.5. Why is this happening now? The government runs on a fiscal year from Oct. 1 to Sept. 30. Shutdowns can happen at other times of the year when Congress passes a partial-year spending bill.6. Could government agencies ignore the shutdown? Under a federal law known as the Anti-Deficiency Act, it can be a felony to spend taxpayer Continue Reading

Questions and Answers

Be Flexible On Your Salary Q. I recently was offered a political-consulting assignment with a group I have known for almost a decade. It's a long-term assignment doing work I love. When I quoted my hourly rate, they said they could only pay me 90 percent of that amount. I'm inclined to agree to their terms – I'm so excited by the assignment that I would do it for half that amount. In addition, based on the calls I have made to some colleagues, I believe I will be earning well within the range of what other consultants in my field make. Still, I'm having second thoughts. I don't want to behave too much like a "good girl" by giving in too easily on my price. Should I fight for the rate I originally quoted? A. Your reasons for accepting their rate are completely sound: You love the work and, you will be paid fairly. Seal the deal. I will not tell anyone that you would do the job at half price, but I appreciate your honesty. While that is obviously a sentiment that you should keep to yourself, it is a telling clue that this assignment is a perfect match for you. Enjoy it, and more will likely follow. Don't Be Too Pushy Q. I had an interview and got a good feeling about the whole process. I wrote the thank-you note to follow up on the interview and made a follow-up phone call asking whether any final decisions had been made. Now three weeks have passed, and I still haven't heard anything. What now? I don't want to be a pest and understand that there are probably many interviews being conducted, but what would be the standard post-interview process? A. Striking the right balance between showing yourself to be an interested applicant and being so pushy that your persistence counts against you is a common dilemma. Three weeks without hearing anything is about the right amount of time to wait before contacting your interviewer again. The key to avoiding this dilemma, however, is being proactive rather than reactive, says Ed Buchholz, vice Continue Reading

VICTIMS & TERRORISTS ON FILM. Docu focus is questions, not answers

A NEW YORK mother tearfully cursed the sons of jihad who took the life of her only son on 9/11. A mother in Palestine praised her son for carrying out a terrorist act in the name of jihad. Everyone has a story to tell in Vladimir Sinelnikov's new ambitious film project - a 12-part series, "The Third World War," which looks at terrorism in recent history from the points of view of world leaders, the victims' families and the perpetrators. "It's a collective of people who would never sit down at the same table together. It provides them with an arena to discuss their issues," said Sinelnikov, a renowned producer, who screened parts of his unfinished documentary at the United Nations last week. "It's an international film. But this is not a film about answers; it's a film about questions," said Sinelnikov, a self-described pessimist regarding the future of the world. "Sadly, humanity is on a brink - the meter is on, and there isn't time." The film, which Sinelnikov eventually hopes to air around the world, will feature 70 to 80 interviews. Although Sinelnikov admits that it was often very difficult for him and his staff to remain completely objective while conducting their interviews, he calmly sat through an interview with a Palestinian man at an Israeli prison who killed two innocent women at a bus stop. "I asked him if he were released if he would do it again," recalled Sinelnikov before showing the interview on the projector. Without hesitation, the man on the tape said, "Yes." "When I spoke to him, I understood that it's impossible to find a compromise with some people, but it's just as important to hear them out," he said. Perhaps the most powerful footage is an interview with Shamil Basayev, who orchestrated the heartless attack on a Russian school in Beslan that led to some 330 deaths, including those of 190 children. The documentary also includes the reflections of such world figures as Henry Kissinger, Rudy Giuliani and Mikhail Continue Reading