BNET Focus on Antidepressants: Part 1, Sales and Strategy

Last Updated Sep 30, 2008 9:00 AM EDT Ever since Eli Lilly launched Prozac in the U.S. in 1987, Americans have had a love affair with anti-depressants. Prozac isn't just a pill. It was the cultural touchstone of 1990s -- as a lifesaver, punchline and punching bag. When Prozac went off-patent in 2001, something interesting happened: the market for new anti-depressants stayed robust instead of being swept away by cheap generics. Today, branded antidepressants are a $2.4 billion-per-quarter market that is still growing. This remarkable mix of business, psychiatry and chemistry deserves a closer look. This is the first of three posts in which BNET will look at the state of the branded antidepressant market in the wake of Prozac. Part 1, today, deals with current sales and strategies. Part 2 will look at controversies in the category. And Part 3 will examine the future of the market as more pills head toward generic status. Second quarter sales of branded antidepressants: Effexor XR ... Wyeth ... $1.02 billion Lexapro ... Forest Labs ... $583 million Cymbalta ... Eli Lilly ... $519 million Paxil CR ... GSK ... $253 million Total: ... $2.4 billion The market is essentially divided into two halves: Cymbalta and Effexor vs. Lexapro and Paxil. This is because Cymbalta (pictured) is growing at 26% and Effexor is growing at 5% (off the largest base). By contrast, Paxil sales declined by 18% (in part due to currency exchange bias) and Lexapro's dollar sales were only up a relatively anemic 5.6%, and it is losing share, according to Deutsche Bank. Now that Paxil has gone generic, GlaxoSmithKline is essentially trying to keep alive a brand that is essentially in a zombie state. What's interesting here is that while generic Paxil is eating Paxil CR alive, Wyeth has essentially the same problem with generic Effexor and Effexor XR and yet has held onto a massive amount of business. This is due in Continue Reading

After A Month, The 7 Questions Hillary Clinton Answered From The Media

Facebook Twitter Flipboard Email Enlarge this image Democratic presidential hopeful Hillary Clinton speaks at a small-business forum at Bike Tech bicycle shop Tuesday in Cedar Falls, Iowa. Scott Olson/Getty Images hide caption toggle caption Scott Olson/Getty Images Democratic presidential hopeful Hillary Clinton speaks at a small-business forum at Bike Tech bicycle shop Tuesday in Cedar Falls, Iowa. Scott Olson/Getty Images Until Tuesday, it had been almost a month since Hillary Clinton had answered a question from the press. After taking questions from Iowans in Cedar Rapids, where she spoke about small business, the former secretary of state then answered six questions from reporters. She also took an awkwardly timed one about whether she'll answer questions from media in the middle of the event. The questions after the event ranged from the release of her emails when she was secretary of state and criticism over foreign donations to the Clinton foundation to the state of Iraq and more. Tamara Keith: State Department To Release Hillary Clinton Emails By January 2016 May 19, 2015 That brings the total number of questions Clinton has answered since she launched her campaign, by NPR's count, to 20. As NPR's Tamara Keith reported recently, Clinton had answered only 13 questions from the media since launching her campaign. That count included a few substantive answers, and many versions of "How are you liking Iowa?" It's All Politics Tamara Keith: The 13 Questions Hillary Clinton Has Answered From The Press It's also something Republicans, like Jeb Bush and Rand Paul, had started to use against her, noting that they were answering questions. During Tuesday's event, Fox News reporter Ed Henry asked if Clinton would be taking questions from the media. (We guess that counts.) "We haven't heard from you in a month," he said. Clinton said to laughs that she would. "Maybe when I finish talking to the people Continue Reading

Working Strategies: Mastering the behavioral interview question – part 1 of 2

It’s been a while since I’ve tackled the infamous behavioral interview question, although readers ask about this topic fairly often. These are the questions based on the idea that how you’ve acted under certain circumstances in a past job is how you’ll act under the same circumstances in a new job. The questions themselves can seem innocent but they manage to leave the average job candidate feeling frozen and bug-eyed like a deer in the headlights. Here are just a few of these tricky fellows: • “Tell us about a conflict you’ve been in with your boss and how you handled it.” • “Give us an example of a difficult customer and how you served him or her.” • “When have you made money for your department?” • “What’s your most notable work achievement?” If those don’t sound tricky to you, you’d better keep reading. Part of the issue with these questions is how innocuous they sound, until you’re knee deep in a story that you wish you’d never started. For example, here’s a bad answer to the question about conflict with a boss: “When my boss announced a new process for handling invoices, she didn’t realize the extra steps could actually increase errors. It was also causing stress for some team members because of the extra workload. When I brought this up to her, she decided to continue with the process anyway, which created some issues … ”I’m not even going to finish that answer because you already see the problem: This candidate is digging a hole by saying her boss initiated a process without understanding its impact, and she’s making the hole deeper by getting lost in he-said-she-said detail. How does that sound to the boss interviewing her from across the table? When it comes to behavioral questions about bosses, or conflict in general, I actually recommend not answering the question. Here’s how Continue Reading

Don Nelson talks, Part 1: “We’ll try to accommodate (Jackson’s trade request) if it’s the right thing for the team”

Don Nelson was fairly serene today at his pre-camp media session, taking on all questions without a bubble of acrimony–a far cry from the tense end of last season. This is the first part of the long session, with six reporters, and the meaty part of this is Nelson talking about Stephen Jackson’s recent trade request. Nelson said he approached Jackson LAST YEAR to see if Jackson might want to be traded, knowing that many losses were coming with the rebuilding project, so he wasn’t too surprised by Jackson’s feelings now. And he said he’d try to accommodate Jackson, but only if it works for the Warriors–tellingly, Nelson said the trade of Al Harrington, under similar circumstances last year, did not work out well and he wishes he didn’t do it. Oh, it’s also telling because it’s Nelson all but confirming that he’s the real GM. He asked Jackson if he wanted to be traded last year, with Chris Mullin still around, and he’s running the trade show now, with Larry Riley supposedly installed as the GM. MORE TO COME…. —DON NELSON media session, transcript Part 1/ –Intro: Fire away. -Q: As you head into camp, do you think this team is good enough? -NELSON: Good enough? -Q: Good enough to be in the playoffs? -NELSON: (Laughs). I don’t know. It’ll work itself out. I will say that we’ve dedicated ourselves to building a team here. I feel very good about what we’re doing. I really like our young players and think we’re doing it the right way. I’ve built teams a lot of times, here several times, and I really like what we’re doing. I feel… I’m excited about the young players. We’ve got eight guys 24 and under. And they’ll take us as far as we’ll go. -Q: So what stage are you in now in this building process? -NELSON: We’re right on schedule. Depends on their maturity. I’d say they’re all on schedule, you know. Continue Reading

College Picks, Bowl Season Part 1: Early calls with San Diego State, VaTech and Duke

We’ll split the bowl season into three parts for the purposes of this series. -Part 1: Games from Saturday’s first games through Dec. 28’s Meineke Car Bowl (14 total games). -Part 2: Games from Dec. 29 through the early portion of the New Year’s Day slate, ending with the Capital One Bowl (13 total games). -Part 3: Games from the Jan. 1 Rose Bowl through the Jan. 6 BCS championship (8 total games, including two minor ones). For Part 1, I was going to take San Jose State minus the number vs. Bowling Green, but with the coaching switch-over… not so much. I’ve got the Spartans in my picks for the Royce Feour Las Vegas Bowls Contest, though. (Turned in the picks before Mike MacIntyre’s departure.) —– KAWAKAMI (last edition 1-2, overall 25-15-2)/ * SAN DIEGO STATE +2.5, over BYU in the Poinsettia Bowl Dec. 20: Fairly even match-up–these are two pretty good, well-coached teams that have something to prove in the finale. I know BYU played a much tougher schedule (lost to  Notre Dame, Boise State, Oregon State, Utah and San Jose State), but I’ll go with SDSU because they’re at home, they’ve won 7 in a row, and the game is quick enough after the regular season to keep the momentum in tact (I’m guessing). * DUKE +7, over Cincinnati in the Belk Bowl Dec. 27: Going with one of my favorite coaches–David Cutcliffe–to carry me vs. a Cincinnati team transitioning from Butch Jones to Tuberville. * VIRGINIA TECH -2.5, over Rutgers in the Russell Athletic Bowl Dec. 28: Awful year for the Hokies; sometimes that coalesces in one last game, especially for a QB like Logan Thomas, after a chance to re-think some things; sometimes it doesn’t. VaTech could get blown out, but I’m going with the more talented favorite. —– PURDY (last edition 0-1, overall 5-9)/ * UTAH STATE – 10.5, over Toledo in the Famous Idaho Potato Bowl on Saturday. Purdy comment: My college Continue Reading

10 questions (and some answers) concerning NBC’s Olympics coverage

By Pete Dougherty Published 4:01 pm, Thursday, February 22, 2018 Photo: JAMES HILL Image 1of/1 CaptionClose Image 1 of 1 Terry Gannon, Tara Lipinski and Johnny Weir, who lead NBC’s figure skating coverage, during the 2018 Winter Olympics in Gangneung, South Korea, Feb. 14, 2018. Scott Hamilton, the face of olympic figure skating coverage for almost a quarter century, has taken a back seat to the new guard of analysts, Lipinski and Weir. (James Hill/The New York Times) -- NO SALES -- less Terry Gannon, Tara Lipinski and Johnny Weir, who lead NBC’s figure skating coverage, during the 2018 Winter Olympics in Gangneung, South Korea, Feb. 14, 2018. Scott Hamilton, the face of olympic figure ... more Photo: JAMES HILL 10 questions (and some answers) concerning NBC's Olympics coverage 1 / 1 Back to Gallery We're down to a few days remaining in Pyeongchang and the Winter Olympics, which have taken over NBC's airwaves since shortly after the Super Bowl. Here are 10 questions that have been raised during the coverage: Where have the viewers gone? In offering numbers to measure its audience, NBC is dispensing a "total audience delivery" figure, which includes broadcast, cable and digital prime-time viewing. Even with that metric, the TAD audience through 12 days is 21.1 million, a 7 percent drop from Sochi in 2014 and 16 percent lower than Vancouver in 2010. That said, the Olympics still demolishes all other prime-time programming. Can a sports nerd be a host? Bob Costas may carry a Mickey Mantle card in his wallet, but he resonated with all audiences, regardless of their familiarity with sports. Fellow Syracuse grad Mike Tirico, nearly 15 years younger, is an admitted sports nerd, but NBC hasn't seemed to lose anything by having him replace Costas as prime-time host. Where did the Continue Reading

Peskin wants monthly Question Time with mayor to have actual questions

By Rachel Swan Updated 6:00 am, Tuesday, January 30, 2018 Photo: Santiago Mejia, The Chronicle Supervisor Aaron Peskin wants more back and forth during the Board of Supervisors monthly Question Time with the mayor. Buy this photo Supervisor Aaron Peskin wants more back and forth during the Board... San Francisco’s “Question Time” — a long-standing monthly appearance by the mayor before the Board of Supervisors — was meant to trigger serious debate between the two branches of government. But in the 12 years since voters approved the practice, it’s become a stock ritual in which no questions are asked. Instead, the supervisors sit patiently while the mayor delivers a five-minute prepared speech. The last time a supervisor submitted a question was in September 2016, according to board clerk Angela Calvillo. “It’s made a farce of what the voters voted for,” said Supervisor Aaron Peskin, who is sponsoring an ordinance to revamp the rules for these question-and-answer sessions. Under his proposal, supervisors would no longer have to present questions ahead of time — rather, they would submit the “general topic” of each question a week before the mayor’s scheduled appearance. Peskin’s ordinance would also allow the mayor and supervisors to ask follow-up questions of each other, encouraging a back-and-forth exchange. Question Time would be split up among districts so that up to four supervisors would be eligible to cross-examine the mayor each month. The idea: to create a lively discourse on city policies, modeled after a British government proceeding in which the prime minister answers questions from Parliament. That was what former Supervisor Chris Daly envisioned when he and three other progressives devised the original Question Time ballot measure in 2006, hoping it would force debate with then-Mayor Gavin Newsom. Continue Reading

Got legal questions? Get legal answers; free legal consultations available on MLK holiday at 8 NWI locations

Area residents can consult with a lawyer free of charge at eight Northwest Indiana locations in four counties on Monday, the Martin Luther King Jr. holiday. Now in its 17th year, Talk to a Lawyer Today brings together some 80 attorneys from various NWI bar associations, said Stephanie Wicke, of Hobart-based NWI Volunteer Lawyers Inc., about this public service pro bono program of the Indiana Bar Association and the Indiana Supreme Court. “We get all kinds of questions especially about family law — wills, estates,” Wicke said. Other inquiries deal with such topics as foreclosures, civil rights, nonprofits, identity theft and employment and wages, she said. Locations and times vary by county. LAKE COUNTY • Tabernacle Baptist Church, 3715 Butternut, East Chicago, from 8:30 a.m. to 1 p.m. • Westside High School, 9th and Gerry streets, Gary, from 9 a.m. to 1 p.m. • Lake Station/New Chicago Public Library, 2400 Central Ave., Lake Station, from 10:30 a.m. to 6:30 p.m. • Lowell Public Library, 1505 E. Commercial Ave., from 9 5 p.m. PORTER COUNTY • Valparaiso University Law Library, 656 S. Greenwich St., from 9 a.m. to 5 p.m. • Portage Township Trustee’s Office, 3484 Airport Road, from 8 a.m. to 4 p.m. JASPER COUNTY • Jasper County Community Services, 967 E. Leopold, Rensselaer, from 10 a.m. to 4 p.m. NEWTON COUNTY • Morocco Community Library, 205 S. West St., from 9:30 a.m. to 4:30 p.m. Phone-in questions will be answered in English and Spanish from 2 to 4 p.m. on Jan. 15 by calling 800-266-2581. Continue Reading

My Interview With IBM’s Vice President of Blockchain Technologies, Jerry Cuomo — Part 1

Image source: IBM. While 2017 may be the year in which bitcoin took the investing world by storm, 2018 may be the year when bitcoin's underlying technology, the blockchain, takes the business world by storm. In fact, IBM (NYSE: IBM) CEO Ginni Rometty said earlier this year that, "What the internet did for communications, I think blockchain will do for trusted transactions." Bitcoin was conceived as a peer-to-peer currency with no central authority, in which the underlying blockchain technology was so transparent and un-alterable that no government entity was needed to govern transactions. That transparency and security is what is so attractive -- and perhaps revolutionary -- to industries such as global finance, shipping, and food safety. Of course, large corporations need a trusted party to run their blockchain networks. With its decades of experience in operating technologies for business, IBM is an early mover in this space. I was recently afforded the opportunity to hold an exclusive interview with Jerry Cuomo, IBM's vice president of blockchain technologies, to learn more about IBM's active blockchain networks -- some of which are already very large and mature -- as well as the technology behind them. In Part 1 below, we'll go over some of what Cuomo had to say about the high-level picture of what blockchain is and how it is being used already by a variety of industries. In Part 2, I go over what he had to say about how blockchain works in IBM's cloud, how the technology was conceived in the Hyperledger Project, and the current competitive dynamic implementing this open-source technology. Here are some of the highlights from my conversation with Cuomo. IBM provided the transcript. I edited some of the quotes for clarity. Blockchain for business I asked Cuomo to describe from a high-level perspective what blockchain technology is, from IBM's perspective. He said: I think there are two sides to the coin of blockchain. One is a social phenomenon, Continue Reading

Putin submits endorsement papers with election authorities

MOSCOW (AP) — Russian President Vladimir Putin has submitted his endorsement papers with election authorities. Putin is running for his fourth term in office as an independent candidate. The law requires all independents to secure an endorsement from at least 500 people. If given the green light, the candidate will then be allowed to collect signatures necessary to be allowed on the ballot. Putin's visit to the Central Election Commission on Wednesday comes a day after a group of his supporters, ranging from lawmakers to athletes, signed up to his nomination. Putin's most formidable foe Alexei Navalny submitted his papers on Sunday but the bid was rejected Monday because of a criminal conviction he and supporters consider political retribution. With approval ratings around 80 percent, Putin poised to easily win the March vote. Continue Reading