After a yearlong search for existing drugs that might help COVID-19 patients and point to a cure, a UCSF-led science team has identified what they say is an especially promising candidate: an anti-cancer drug that kills the coronavirus in lab studies and is almost 30 times more potent than remdesivir, one of the few antiviral drugs available to treat the disease. The new peer-reviewed research, published Monday in the journal Science, highlights a drug called Aplidin, which was originally extracted from an exotic marine creature called Aplidium albicans — a type of “sea squirt” found off the coast of Ibiza that looks a bit like a disembodied brain. Aplidin, also known as plitidepsin, is owned by Pharma Mar, a Spanish company founded by a scuba-diving scientist. Approved in Australia to treat multiple myeloma, a type of blood cancer, the drug isn’t commercially available in most parts of the world and isn’t yet approved to treat COVID-19, though it has been tested in a few dozen COVID-19 patients in Spain. “We need some new weapons in the arsenal,” said Nevan Krogan, a UCSF molecular biologist who led the science team along with Adolfo García-Sastre, a virus expert at the Icahn School… Read full this story
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