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Researcher seeks to stop Alzeheimer’s disease at its source

July 14, 2019 by oklahoman.com Leave a Comment

A scientist who studies how dopamine works in the brain will use a $400,000 grant to investigate clues that the chemical may have a role in Alzheimer’s disease. The information could be used to shut down the degenerative process at the beginning, before patients lose brain cells and memory they will never get back.

“All therapeutic treatments (for Alzheimer’s) are symptomatic. They can’t slow down the disease,” said Michael Beckstead, who works in the Aging & Metabolism Research Program at the Oklahoma Medical Research Foundation.

“Once brain cells are dead, they can’t come back,” Beckstead said. “If we catch it early on before the cells really start dying off, we could develop therapies to arrest the process in its earliest stages before any cognitive damage is done.”

That will require a way to diagnose Alzheimer’s sooner because it usually isn’t diagnosed until memory loss has set in.

Some of the earliest symptoms are depression and apathy, which involve areas of the brain Beckstead studies.

“People with depression and apathy are much more likely to develop Alzheimer’s later in life,” he said.

With the new grant from the National Institute on Aging, he will be studying dopamine neurons in the brains of mice with Alzheimer’s and of mice who are old (about 2 1/2 years) but don’t have the disease.

The grant is a supplement to an initial $1.7 million NIA award Beckstead received to investigate how the dopamine system ages in the brain. When the system produces too little dopamine, it can cause movement disorders like Parkinson’s disease, as well as depression.

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Filed Under: HealthNews oklahoma city, okc, Health, News, Kathryn mcnutt, how to stop gum disease, how to stop periodontal disease, stop gum disease, US Army Medical Research Institute of Infectious Diseases, infectious disease research, Disease Research, Disease Researchers, rare diseases clinical research network, autoimmune disease research, infectious disease research institute, source global research, Infectious Diseases Research, heart disease research, Alzheimer Disease Research Center, Veneral Disease Research Laboratory, Center for Infectious Disease Research and Policy, cardiovascular diseases research

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